Neuropathology

Evaluating the Nervous System

StageBio is an industry leader in the field of neuropathology. The StageBio neuropathology team, including Dr. Mark Butt, have dozens of years of experience in evaluating the complex effects of the nervous system, in addition to general toxicology evaluations. Before your study starts, our pathologists can offer advice about vital control groups, appropriate group sizes, necessary experimental time points, tissue sampling strategies, optimal tissue fixation and processing, and important histochemical stains and immunohistochemical labels. Our pathologists will work with you to assist in GLP compliance and regulatory submission.

Neuropath computer use

Neuropathology areas of expertise include protocol development and design for GLP regulatory submissions.  Assistance with pilot studies for unique investigative approaches and method development for specialized investigations and techniques are also available.  Other specialties include:

  • Direct delivery (intrathecal, intracerebroventricular, intraparenchymal including intrastriatal, intrahippocampal, etc.)
  • In-dwelling catheter administration
  • Adeno-associated vectors (AAV)
  • Deep brain stimulation
  • Nerve stimulation and cryoablation
  • Evaluation of specialty neuroscience tissue processing investigations (frozen sections… like NSA studies)
  • Juvenile neurotoxicity studies

StageBio specializes in advanced trimming techniques for central and peripheral nervous system tissues, including brain, spinal cord, sympathetic and parasympathetic ganglia, and peripheral nerves. Our histology technicians are highly trained in obtaining and handling these difficult and sensitive tissues. We offer brain and spinal cord trimming/sectioning schemes for detailed neurotoxicity studies that will help to ensure that the complexities of the nervous system are fully captured.

 

For specialized tissues - such as peripheral nerves - StageBio offers osmication and ultra-thin sectioning of tissues embedded in plastic (resin), allowing for the evaluation of structures that would otherwise not withstand standard processing methods (for example, myelin).  StageBio also has the ability to produce thick frozen sections up to 50 microns from fixed tissue. These thick sections are crucial for the application of stereologic and intraepidermal nerve fiber density investigations, where multiple focal planes are essential for performing accurate quantitative analyses. Frozen sections also allow for improved immunohistochemistry due to the relative lack of processing reagents needed in standard paraffin processing, as well as the ability to stain frozen sections free-floating, allowing for better antibody penetration.

Common Questions

01.

Can StageBio assist with regulatory submissions?

Yes - StageBio has staff and experience regarding GLP compliant regulatory submissions .

02.

Can you provide frozen sections?

Yes -StageBio also has the ability to produce thick frozen sections up to 50 microns from fixed tissue.

03.

Can you handle advanced trimming techniques?

Our histology technicians are trained to process nervous system tissues, including brain, spinal cord, sympathetic and parasympathetic ganglia, and peripheral nerves. 

The StageBio Lab Services Team is trained in a variety of areas to meet our clients' needs.

MEET THE LAB SERVICES TEAM

StageBio is a proud supporter of the National Society for Histotechnology and the Society of Quality Assurance.

Testimonials

I have evaluated thousands of slides that VPS [now StageBio] has prepared. Their consistency from slide to slide is remarkable. It makes my job as a pathologist much easier when we contract our work to VPS [now StageBio]!”

Director of Pathology
Contract Research Organization

We've always found the quality of work and GLP reporting we receive from HSRL [now StageBio] to be top notch. Good customer service is hard to come by, but that is one of the things that keeps us coming back.”

Assistant Director of Medical Devices
Medical Device CRO

Contact Us

Contact us to discuss your Neuropathology needs!


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