Content Library

StageBio pathologists were members of the STP SRPC Medical Device Implant Site Evaluation working group that published a recent Points to Consider article in Toxicologic Pathology

Complex biological responses are induced by implanted medical devices, and nonclinical studies are a common and often critical step for the safety assessment of these devices.

StageBio pathologists co-author article on the underestimated role ASN (autophagy of sensory neurons) plays in sensory ganglia

Many pathologists do not evaluate sensory ganglia in cynomolgus monkeys (Macaca fascicularis) during nonclinical toxicology investigations.

StageBio Pathologists Co-author Article Demonstrating Wound Dressings with High Evaporation Rates Improve Healing

Proper and effective wound care mandates the controlling of the homeostatic wound state.

StageBio pathologist co-authors review on contributing lifestyle factors of oral cancer

The National Toxicology Program (NTP) has conducted more than 500 short-term and 2-year toxicology and carcinogenicity studies in rodents: throughout the course of these studies, several chemicals tested contributed to the development of oral cancer.

The use of 3D-printed scaffolds to treat midfacial critical-sized bone defects

StageBio senior pathologist co-authors study on the use of 3D-printed bioactive scaffolds for restoring midfacial bone defects.

StageBio pathologists are members of the INHAND working group for CNS and PNS of the rat and mouse

IThe International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (INHAND) has published an article, “Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems: New and Revised INHAND Terms,” which can be accessed here. This article revises two existing terms and defines nine new terms for the rat and mouse central nervous system (CNS) and peripheral nervous system (PNS).

StageBio pathologist co-authors study on shape memory polymer foam-coated coils for the treatment of aneurysms

Healthcare providers often rely on embolic coils to isolate a patient’s aneurysm from artery blood flow and prevent rupturing. However, embolic coils are associated with complications such as recanalization, compacted coils (as a result of pulsing arterial flow), improper healing of an aneurysm, and others—all of which may result in the growth or rupturing of an aneurysm, as well as the creation of additional aneurysms.

StageBio senior pathologist co-authors article on the use of animal models of disease for nonclinical safety testing

Currently, healthy animal models play a critical role in the safety evaluation of a drug or health product. However, pharmaceutical companies and regulatory authorities are becoming increasingly interested in the use of animal models of disease (AMD) to better understand the potential risk of a diseased population. Recent publications and recommendations for the use of these models by regulators make the growing interest of the application of AMD highly evident.

Evaluating the safety of a self-amplifying mRNA vaccine in rats

What is self-amplifying mRNA technology? Self-amplifying mRNA (SAM) technology is a relatively novel approach in vaccinology. It consists of an engineered replication-deficient alphavirus genome encoding an RNA-dependent RNA polymerase and the gene of the target antigen. The benefit that SAM technology holds over conventional vaccinology is its potential for the rapid development and large-scale production of a vaccine in the event of an unpredictable epidemic outbreak.

3 Keys to Successful Pathology Endpoints in Inhalation Toxicology Studies

In a recent ACT 2021 Talking Tox webinar titled “Safety of E-Cigarette Products – A Toxicological Challenge,” I provided scientific guidance on pathology endpoints for inhalation studies. During my segment, I discussed the special planning necessary to optimize histopathology results when studying test articles dosed via the inhalation route (nose-only, head, or whole-body exposure).

IHC or IF: Which is Best for My Study?

Immunohistochemistry (IHC) and immunofluorescence (IF) are molecular assays that involve the use of antibodies to detect specific proteins within tissues on microscope slides

GLP & Non-GLP: What's the Difference?

Good Laboratory Practices (GLP) refers to a system where non-clinical health and safety studies are carried out, planned, monitored, recorded, archived and reported. 

Upcoming Events

ESMO Congress 2022

Date: September 9-13, 2022
Location: Paris, France
The StageBio team is looking forward to attending ESMO Congress 2022 in Paris, France, September 9-13, and we hope to see you there!

Learn more about StageBio’s COVID-19 response