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Evaluating the safety of a self-amplifying mRNA vaccine in rats

What is self-amplifying mRNA technology? Self-amplifying mRNA (SAM) technology is a relatively novel approach in vaccinology. It consists of an engineered replication-deficient alphavirus genome encoding an RNA-dependent RNA polymerase and the gene of the target antigen. The benefit that SAM technology holds over conventional vaccinology is its potential for the rapid development and large-scale production of a vaccine in the event of an unpredictable epidemic outbreak.

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ASGCT (American Society of Gene and Cell Therapy)

May 16-19, 2022, Walter E. Washington Convention Center, Washington, D.C.

Society of French Pathology Toxicology

May 19-20, Toulouse, France
Listen to our presentation by Dr. Serge Rousselle, CSO, on the scientific value of histopathological evaluation during the nonclinical safety assessment of medical devices

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