While the Marburg virus disease (MVD) is deadly to humans, the filovirus responsible for it—i.e., the Marburg virus (MARV)—is carried asymptotically in Egyptian rousette bats (ERBs).
While the Marburg virus disease (MVD) is deadly to humans, the filovirus responsible for it—i.e., the Marburg virus (MARV)—is carried asymptotically in Egyptian rousette bats (ERBs).
When it comes to preclinical research and clinical trials, the logistics outside the lab are as crucial as the processes and handling of samples inside the lab. In other words, frozen samples must be handled with care and transported in a timely manner to make sure project milestones are reached.
The limitations of current PFO occluders According to the Mayo Clinic, approximately one in four people have a hole between the left and right chambers of the heart known as a patent foramen ovale, or PFO. First-generation PFO occluders were designed to stop any resulting blood flow between the two chambers.
StageBio scientists co-author study that demonstrate the benefit of 3D-printed scaffolds with geometric mismatches to treat periorbital bony defects
Toxicologic pathologists play a critical role in helping to determine the immunosafety of biopharmaceutical therapies.
Products such as cytotoxic chemotherapeutics and AAV-based gene therapies are associated with gangliotoxicity. Despite this, prior toxicology guidance provided no recommendations for which sensory and autonomic ganglia to evaluate in nonclinical general toxicity studies.
A published review on the broadening applications of ISH in drug research and development
While the connections between TP53 mutations and cancer have been well studied, an estimated 200 missense variants remain unclassified.
While a link has been observed between bacterium and the development of gastric and colorectal cancer, there has been little evidence to suggest a connection between intestinal microbiota and the carcinogenesis of extra-intestinal organs.
StageBio pathologist Dr. Shannon Kirejczyk authored a 2023 paper to evaluate host responses and virus clearance in Egyptian rousette bats (ERBs) experimentally infected Kasokero virus (KASV) using histopathology and whole-slide digital image analysis.
To better understand the role that the microbiome plays in the formation of gastrointestinal (GI) diseases among captive marmosets, StageBio senior pathologist Dr Sureshkumar Muthupalani partnered with researchers to study a novel GI syndrome
For reasons not fully understood, captive marmosets are commonly diagnosed with chronic gastrointestinal (GI) diseases—more so than other diseases.
To understand how various rates of water evaporation impact wound healing, StageBio director of digital and quantitative pathology Dr. Thomas Lemarchand and Image Analyst Fabian Kukla co-authored a study to test in vitro and in vivo water evaporation rates from the cellulose dressing epicitehydro when combined with different secondary dressings.
Whitepaper Addresses Challenges of Bioabsorbable Implants in Preclinical Animal Studies and Data Interpretation.
Complex biological responses are induced by implanted medical devices, and nonclinical studies are a common and often critical step for the safety assessment of these devices.
Many pathologists do not evaluate sensory ganglia in cynomolgus monkeys (Macaca fascicularis) during nonclinical toxicology investigations.
Proper and effective wound care mandates the controlling of the homeostatic wound state.
The National Toxicology Program (NTP) has conducted more than 500 short-term and 2-year toxicology and carcinogenicity studies in rodents: throughout the course of these studies, several chemicals tested contributed to the development of oral cancer.
StageBio senior pathologist co-authors study on the use of 3D-printed bioactive scaffolds for restoring midfacial bone defects.
IThe International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (INHAND) has published an article, “Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems: New and Revised INHAND Terms,” which can be accessed here. This article revises two existing terms and defines nine new terms for the rat and mouse central nervous system (CNS) and peripheral nervous system (PNS).
Healthcare providers often rely on embolic coils to isolate a patient’s aneurysm from artery blood flow and prevent rupturing. However, embolic coils are associated with complications such as recanalization, compacted coils (as a result of pulsing arterial flow), improper healing of an aneurysm, and others—all of which may result in the growth or rupturing of an aneurysm, as well as the creation of additional aneurysms.
In a recent ACT 2021 Talking Tox webinar titled “Safety of E-Cigarette Products – A Toxicological Challenge,” I provided scientific guidance on pathology endpoints for inhalation studies. During my segment, I discussed the special planning necessary to optimize histopathology results when studying test articles dosed via the inhalation route (nose-only, head, or whole-body exposure).
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