Content Library

Whitepaper Addresses Challenges of Bioabsorbable Implants in Preclinical Animal Studies and Data Interpretation.

Complex biological responses are induced by implanted medical devices, and nonclinical studies are a common and often critical step for the safety assessment of these devices.

Many pathologists do not evaluate sensory ganglia in cynomolgus monkeys (Macaca fascicularis) during nonclinical toxicology investigations.

Proper and effective wound care mandates the controlling of the homeostatic wound state.

The National Toxicology Program (NTP) has conducted more than 500 short-term and 2-year toxicology and carcinogenicity studies in rodents: throughout the course of these studies, several chemicals tested contributed to the development of oral cancer.

StageBio senior pathologist co-authors study on the use of 3D-printed bioactive scaffolds for restoring midfacial bone defects.

IThe International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (INHAND) has published an article, “Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems: New and Revised INHAND Terms,” which can be accessed here. This article revises two existing terms and defines nine new terms for the rat and mouse central nervous system (CNS) and peripheral nervous system (PNS).

Healthcare providers often rely on embolic coils to isolate a patient’s aneurysm from artery blood flow and prevent rupturing. However, embolic coils are associated with complications such as recanalization, compacted coils (as a result of pulsing arterial flow), improper healing of an aneurysm, and others—all of which may result in the growth or rupturing of an aneurysm, as well as the creation of additional aneurysms.

In a recent ACT 2021 Talking Tox webinar titled “Safety of E-Cigarette Products – A Toxicological Challenge,” I provided scientific guidance on pathology endpoints for inhalation studies. During my segment, I discussed the special planning necessary to optimize histopathology results when studying test articles dosed via the inhalation route (nose-only, head, or whole-body exposure).