Content Library

Journal Article Offers Insights on Toxicologic Neuropathology of Novel Biotherapeutics

Biotherapeutics like cell and gene therapies, nucleic acids, and proteins show promise for treating many neurodegenerative disorders.

Paper Provides New Insights into the Immunological Resistance of MARV Virus in Bats

While the Marburg virus disease (MVD) is deadly to humans, the filovirus responsible for it—i.e., the Marburg virus (MARV)—is carried asymptotically in Egyptian rousette bats (ERBs).

Opinion Article Proposes Practical Framework for Evaluating and Assessing Adversity of Immune System Changes When Evaluating Immune-Modulating Therapeutics

Toxicologic pathologists play a critical role in helping to determine the immunosafety of biopharmaceutical therapies.

StageBio senior pathologist co-authors article on the use of animal models of disease for nonclinical safety testing

Currently, healthy animal models play a critical role in the safety evaluation of a drug or health product. However, pharmaceutical companies and regulatory authorities are becoming increasingly interested in the use of animal models of disease (AMD) to better understand the potential risk of a diseased population. Recent publications and recommendations for the use of these models by regulators make the growing interest of the application of AMD highly evident.

Evaluating the safety of a self-amplifying mRNA vaccine in rats

What is self-amplifying mRNA technology? Self-amplifying mRNA (SAM) technology is a relatively novel approach in vaccinology. It consists of an engineered replication-deficient alphavirus genome encoding an RNA-dependent RNA polymerase and the gene of the target antigen. The benefit that SAM technology holds over conventional vaccinology is its potential for the rapid development and large-scale production of a vaccine in the event of an unpredictable epidemic outbreak.

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