The orthopedic device sector of the medical device industry is fast-growing and constantly evolving. Histopathological evaluation of orthopedic devices provides a critical assessment for determining the safety and efficacy of these next-generation biomaterials, especially with continued advancements in technology and designs of orthopedic devices. Proper evaluation of the biocompatibility of orthopedic implants should include advanced histological imaging and processing techniques to better assess tissue response surrounding the implant and to gauge the potential for adverse effects. This is the seventh and final article in this series where we highlight a portion of the article published by Nicolette Jackson et al. discussing the different types of mechanical testing used during the evaluation of orthopedic devices in preclinical animal studies.